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Cat. No. Product Name CAS No. Information
PC-63323

AB-423

1572510-80-5

AB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM); inhibits HBV genotypes A through D and nucleos/tide-resistant variants, causes capsid particles devoid of encapsidated pgRNA and rcDNA in treated HepDES19 cells, prevents the conversion of encapsidated rcDNA to cccDNA presumably by interfering with the capsid uncoating process; dose-dependently reduces serum HBV DNA levels in mouse model of HBV model, shows synergistic antiviral activity combined with entecavir (ETV).

HBV Infection

Phase 1 Clinical

PC-60044

Inarigivir soproxil

942123-43-5

Inarigivir soproxil (SB-9200, SB9200, Inarigivir, ORI-9020) is an orally bioavailable dinucleotide that activates RIG-I and NOD2, induces interferon mediated antiviral immune responses; shows broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, RSV and influenza, and also demonstrates activity HBV in vitro and in vivo; a novel agonist of innate immunity, and prodrug of Inarigivir (ORI-9020;SB-9000).

HBV Infection

Phase 2 Clinical

PC-63329

Isothiafludine

960527-22-4 Isothiafludine (NZ-4) is a novel HBV capsid assembly inhibitor that inhibits HBV replication through blocking pregenomic RNA encapsidation, suppresses HBV replication in HepG2.2.15 cells with IC50 of 1.33 uM; shows activity against the replication of various drug-resistant HBV mutants, including 3TC/ETV-dual-resistant and ADV-resistant HBV mutants; concentration-dependently reduces the encapsidated HBV pgRNA, resulting in the assembly of replication-deficient capsids in HepG2.2.15 cells; inhibits DHBV DNA replication in the DHBV-infected ducks after oral administration.

HBV Infection

Phase 1 Clinical

PC-63326

GLS4

1092970-12-1 GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM) and reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14 nM), shows efficacy against ADV-resistant HBV mutations; strongly inhibits core gene expression (at 100 to 200 nM), suppresses virus accumulation in the supernantant of HepAD38 cells; inhibits HBV replicative forms in the live, shows strong and sustained suppression of virus DNA in treated mice.

HBV Infection

Phase 3 Clinical

PC-63285

Besifovir

441785-26-8 Besifovir (PMCDG Dipivoxil, NA-380, LB-80380) is a potent, selective, orally available anti-HBV agent, the prodrug of PMCDG (EC50=4 uM).

HBV Infection

Phase 3 Clinical

PC-62776

RG7834

2072057-17-9 RG7834 is a novel orally available small molecule that inhibits HBV viral gene expression, blocks viral antigen and virion production and is selectivie for HBV; inhibits the expression of viral proteins by specifically reducing HBV mRNAs, potentially provides anti-HBV benefits by direct reduction of viral agents needed to complete the viral life cycle; potently reduces the levels of secreted HBsAg, HBeAg and HBV DNA with EC50 of 2.57 to 3.16 nM, reduces HBV total mRNA levels with EC50 of 5.87 nM; reduces both HBV DNA and HBsAg levels in humanized mice.

HBV Infection

Phase 1 Discontinued

PC-62578

RO6889678

1578153-27-1 RO6889678 is a highly potent inhibitor of HBV capsid formation with attributes that are favorable for targeting the liver, whilst maintaining moderate peripheral exposure.

HBV Infection

Phase 1 Discontinued

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