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Cat. No. Product Name CAS No. Information
PC-35646

Gemcabene calcium

209789-08-2 Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP; down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism, inhibits IL-6 plus IL-1β-induced CRP production in a concentration-dependent manner in human hepatoma cells, reaching 70% inhibition at 2 mM; lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), attenuates osteoarthritis and pain in animal models of arthritis and Pain.

Hypercholesterolemia

Phase 2 Clinical

PC-35643

Gemcabene

183293-82-5 Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP; down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism, inhibits IL-6 plus IL-1β-induced CRP production in a concentration-dependent manner in human hepatoma cells, reaching 70% inhibition at 2 mM; lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), attenuates osteoarthritis and pain in animal models of arthritis and Pain.

Hypercholesterolemia

Phase 2 Clinical

PC-63549

Lopixibat chloride

228113-66-4 Lopixibat chloride (LUM-001, HP-625) is a potent, selectiove, oral inhibitor of sodium bile acid cotransporter and Ileal bile acid transporter (IBAT).

Hypercholesterolemia

Phase 2 Clinical

PC-63363

TMP-153

128831-46-9 TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals; inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively); inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.

Hypercholesterolemia

Discontinued

PC-63169

PF-06815345

1900686-46-5 PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay; PF-06815345is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1).

Hypercholesterolemia

Phase 1 Discontinued

PC-61593

BMS-852927

1256918-39-4 BMS-852927 is a highly potent liver X receptor β (LXRβ) agonist with Ki of 12 and 19 nM for LXRβ and LXRα, respectively; demonstrates robust LXRβ activity (88%, EC50=24 nM) with low partial LXRα agonist activity (<25%) in cell assays; exhibits desired blood cell ABCG1 gene induction in cynomolgus monkeys with limited elevation of plasma triglycerides; has favorable combination of in vitro properties, excellent pharmacokinetic parameters, and a favorable lipid profile.

Hypercholesterolemia

Phase 1 Discontinued

PC-44047

Choline Fenofibrate

856676-23-8 A PPARα agonist used for treatment of hyperlipidemia; increases SHP gene expression in cultured liver cells and in the normal and diabetic mouse liver by activating AMPK signaling pathway.

Hypercholesterolemia

Approved

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