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Cat. No. Product Name CAS No. Information
PC-62808

KAR-5585

1673571-51-1

KAR-5585 (Rodatristat) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice; generates high and sustained systemic exposure of the active parent KAR5417 in rats and dogs; orally bioavailable.

Hypertension

Phase 1 Clinical

PC-43467

Nepicastat hydrochloride

170151-24-3 Nepicastat (RS-25560-197, SYN-117) is a potent, selective, orally active inhibitor of dopamine-beta-hydroxylase (DBH) with IC50 of 8.5 and 9.0 nM for bovine and human DBH, respectively; Nepicastat is 2-3 fold more potent than the corresponding R-enantiomer (RS-25560-198); produces dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery, left ventricle and cerebral cortex in spontaneously hypertensive rats.

Hypertension

Discontinued

PC-43466

Nepicastat

173997-05-2 Nepicastat (RS-25560-197, SYN-117) is a potent, selective, orally active inhibitor of dopamine-beta-hydroxylase (DBH) with IC50 of 8.5 and 9.0 nM for bovine and human DBH, respectively; Nepicastat is 2-3 fold more potent than the corresponding R-enantiomer (RS-25560-198); produces dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery, left ventricle and cerebral cortex in spontaneously hypertensive rats.

Hypertension

Discontinued

PC-43394

Ambrisentan

177036-94-1 Ambrisentan (BSF 208075;LU 208075) is a highly selective antagonist of the endothelin-1 type A receptor (ETA) for use in the treatment of pulmonary hypertension.

Hypertension

Approved

PC-43386

CGS 21680 hydrochloride

124431-80-7 CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM; significantly upregulates CD39 and CD73 expression, accelerates the ATP hydrolysis and adenosine generation; reduces the number of infiltrated granulocytes into the ischemic tissue in rat model of transient cerebral ischemia.

Hypertension

Discontinued

PC-43385

CGS 21680

120225-54-9 CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM; significantly upregulates CD39 and CD73 expression, accelerates the ATP hydrolysis and adenosine generation; reduces the number of infiltrated granulocytes into the ischemic tissue in rat model of transient cerebral ischemia.

Hypertension

Discontinued

PC-43177

Midodrine hydrochloride

43218-56-0 Midodrine is a selective α1-adrenoceptor agonist that acts as a vasopressor/antihypotensive agent for the treatment of dysautonomia and orthostatic hypotension; activates the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure; does not stimulate cardiac beta-adrenergic receptors, and diffuses poorly across the blood-brain barrier.

Hypertension

Approved

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