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Cat. No. Product Name Information
PC-21319

PSB-22040

MRGPRX4 agonist

PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively.
PC-49487

Compound 48/80

MRGPRX2 agonist

Compound 48/80 (C48/80) is a polymer produced by condensation of N-methyl-p-methoxyphenethylamine with formaldehyde, activates human MRGPRX2 and MRGPRX1 as well as murine MRGPRB2.
PC-49486

GE1111

MRGPRX2 inhibitor

GE1111 is a novel potent small molecule Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, significantly inhibits mast cells degranulation and MRGPRX2 activation with IC50 of 5 uM.
PC-72741

MRGPRX1 inhibitor 1t

MRGPRX1 modulator

MRGPRX1 inhibitor 1t is a potent, selective, positive allosteric modulator (PAM) of Mas-related G protein-coupled receptor X1 (MRGPRX1) with EC50 of 0.1 uM.
PC-38069

MS47134

MRGPRX4 agonist

MS47134 is a potent, selective MRGPRX4 agonist with EC50 of 149 nM.
PC-38068

MRGPRX2 antagonist C9

MRGPRX2 inhibitor

MRGPRX2 antagonist C9 is a potent and selective MRGPRX2 inverse agonist (antagonist) with Ki of 43 nM.
PC-38067

ZINC16991592

MRGPRX2 inhibitor

ZINC16991592 (ZINC1592) is a selective MRGPRX2 antagonist with Ki of 189 nM.
PC-38066

MRGPRX1 agonist 1

MRGPRX1 agonist

MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist with EC50 of 50 nM, superior selectivity over opioid receptors.
PC-62228

ZINC-3573 racemate

MRGPRX2 agonist

ZINC-3573 racemate is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=3 uM), showing little activity against 315 other GPCRs and 97 representative kinases.
PC-62227

(R)-ZINC-3573

MRGPRX2 agonist

(R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases.

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