| Cat. No. |
Product Name |
Information |
| PC-60047 |
Mavacamten
Cardiac myosin inhibitor
|
Mavacamten (SAR439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain, with IC50 of 490 and 711 nM for bovine cardiac and human cardiac myosin, respectively. |
| PC-45036 |
BTS
myosin II ATPase inhibitor
|
BTS is a highly specific myosin II ATPase inhibitor, inhibits the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility. |
| PC-24900 |
MT-110
Non-muscle myosin II inhibitor
|
MT-110 is a potent, selective, brain penetrant non-muscle myosin II (NMII) inhibitor with EC50 of 0.68 uM in cytokinesis assays, >70-fold selectivity over cardiac muscle myosin II (CMII). |
| PC-24862 |
MT-125
non-muscle myosin II inhibitor
|
MT-125 is a specific, brain penetrant small-molecule inhibitor of non-muscle myosin IIA and IIB (NMIIA and IIB) with Ki of 2.7 uM (NMIIA) and EC50 of 1.7 uM (NMIIB). |
| PC-24122 |
Delocamten
Cardiac myosin inhibitor
|
Delocamten is a potent selective cardiac myosin inhibitor with potential treatment of hypertrophic cardiomyopathy (HCM). |
| PC-23469 |
Calmodulin inhibitor W-7
Calmodulin antagonist
|
W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively. |
| PC-23211 |
MT-228
non-muscle myosin II inhibitor
|
MT-228 is a potent, selective, first-in-class non-muscle myosin II (NMII) inhibitor with Ki of 1.5 uM and cytokinesis EC50 of 1.0 uM, 17-fold selectivity for NMII over cardiac myosin II (CMII). |
| PC-23164 |
Myokinasib-II
MLCK inhibitor
|
Myokinasib-II is a potent and highly selective myosin light-chain kinase (MLCK) chemical probe inhibitor with IC50 of 4.4 uM for MLCK-1. |
| PC-23162 |
ML-9 free base
MLCK inhibitor
|
ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines. |
| PC-22342 |
Divertin
MLCK1 inhibitor
|
Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo. |
| PC-21413 |
Myosin inhibitor F10
Cardiac-myosin inhibitor
|
Cardiac-myosin inhibitor F10 is a cardiac-myosin specific and allosteric inhibitor with IC50 of 23 uM on actomyosin ATPase activity. |
| PC-43535 |
Blebbistatin S enantiomer
|
Blebbistatin S enantiomer ((S)-(-)-Blebbistatin) is the S enantiomer of blebbistatin, which is a potent and selective myosin II inhibitor with IC50 of 0.5-5 uM. |
