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Cat. No. Product Name CAS No. Information
PC-35791

Nebicapone

274925-86-9

Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM; enhances the availability of L-DOPA to the brain and reduces its O-methylation, Nebicapone (BIA 3-202, BIA3-202) is an adjunct to levodopa/carbidopa or levodopa/benserazide in the treatment of Parkinson's disease.

Parkinson Disease

Phase 1 Discontinued

PC-70174

CEP-1347

156177-65-0

CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM; has weak inhibitory activity for Trk A and MLCK; promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade; inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells; elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases.

Parkinson Disease

Phase 2 Discontinued

PC-45425

GNE-7915 tosylate

2070015-00-6

GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.

Parkinson's Disease

Preclinical

PC-45424

GNE-7915

1351761-44-8

A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.

Parkinson's Disease

Preclinical

PC-35468

Tavapadon

1643489-24-0 Tavapadon (PF 6649751, PF-06649751) is an orally available dopamine D1 receptor partial agonist for treatment of Parkinson's disease.

Parkinson Disease

Discontinued

PC-63577

GPI-1046

186452-09-5 GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12; induces ARNT expression with subsequent activation of ALK3-dependent canonical BMP signaling responses and attenuates chronic organ failure in models of chronic kidney, but also cardiac and liver injuries; reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats.

Parkinson Disease

Discontinued

PC-63432

Pridopidine

346688-38-8 Pridopidine (ACR16, FR-310826, ASP-2314, Huntexil) is a specific dopamine stabilizer without no partial agonism; shows robust dose-dependent striatal D2 occupancy with ED50 of 18.99 mg/kg s.c. in vivo, shows high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in rats.

Parkinson Disease

Discontinued

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