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Pleconaril (Picovir, VP-63843, Win-63843) is a broad spectrum antipicornaviral agent that inhibits rhinovirus replication by interaction with the VP1 protein; inhibits EV-D68 with EC50 of 430 nM; shows active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.

Rhinovirus Infection

Phase 2 Clinical



223537-30-2 Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM; potently and irreversibly inhibits HRV 3C protease with an inactivation rate constant (kobs/[I]) of 1,470,000 ± 440,000 M-1 s-1 for HRV 14; also potently inhibits related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11.

Rhinovirus Infection

Phase 2 Clinical



439085-51-5 Vapendavir (BTA798) is a novel potent enteroviral capsid binder, inhibits EV71 replication of all isolates with mean EC50 of 0.7 uM; efficiently inhibits the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, and C; Vapendavir (BTA798) is currently under clinical study for the treatment of rhinovirus infections.

Rhinovirus Infection

Phase 2 Clinical

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