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Cat. No. Product Name CAS No. Information
PC-60214

PF-00446687

862281-92-3

PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.

Sexual Dysfunction

Phase 2 Clinical

 

PC-60213

PF-00446687 hydrochloride

862282-10-8

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.

Sexual Dysfunction

Phase 2 Clinical

 

PC-60063

Enclomiphene citrate

7599-79-3

Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476) is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism; inhibits the ER in the pituitary gland, reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, increases gonadotropin secretion and hence gonadal production of testosterone.

Sexual Dysfunction

Phase 3 Clinical

PC-45520

Bremelanotide acetate

1607799-13-2

Bremelanotide acetate is an analogue of the naturally occurring peptide alpha-MSH; melanocortin receptor agonist.

Sexual Dysfunction

Phase 3 Clinical

PC-61369

Cligosiban

900510-03-4 A potent, specific oxytocin receptor antagonist with Ki of 9.5 nM, displays high selectivity over the vasopressin receptors; demonstrates excellent potency and selectivity, as well as promising in vivo pharmacokinetics and significantly improved aqueous solubility.

Sexual Dysfunction

Phase 1 Discontinued

PC-70138

Bremelanotide

189691-06-3 A peptide, non-selective melanocortin receptor agonist for treatment for female sexual dysfunction; selectively stimulates solicitational behaviors in the female rat, without affecting lordosis, pacing, or other sexual behaviors, does not cause generalized motor activation; a peptide analogue of α-MSH.

Sexual Dysfunction

Phase 3 Clinical

PC-60216

PF-592379

710655-15-5 A potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM; displays >470 and 180-fold functional selectivity over D2 and D4 dopamine receptors, respectively; demonstrates activity in animal models of male erectile dysfunction.

Sexual Dysfunction

Preclinical

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