| Cat. No. |
Product Name |
Information |
| PC-25313 |
TLR7/8 antagonist 1
TLR7/8 antagonist
|
TLR7/8 antagonist 1 is a potent TLR7 and TLR8 antagonist with IC50 of 3.91 uM and 2.19 uM respectively, inhibits agonist induced TNFα, IFNγ, and IL-1β. |
| PC-25312 |
TLR 7/8 agonist 558
TLR7/8 agonist
|
TLR 7/8 agonist 558 (TLR7/8 agonist 6) is a potent TLR7 and TLR8 small molecule agonist with EC50 of 0.18 uM and 5.34 uM respectively, stimulates TNFα, IFNγ, and IL-1β. |
| PC-25128 |
SMU-C80
TLR1/2 agonist
|
SMU-C80 is a highly efficient and specific human TLR1/2 agonist, effectively promotes the SEAP signals in HEK-Blue hTLR2 cells with EC50 of 31.02 nM. |
| PC-25127 |
CU-T12-9
TLR1/2 agonist
|
CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM, directly targets TLR1/2 to initiate downstream signaling, induces TLR1/2 heterodimerization. |
| PC-25126 |
SMU-CX1
TLR3 inhibitor
|
SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity. |
| PC-25125 |
SMU-C68
TLR1/2 agonist
|
SMU-C68 is a potent, selective human TLR1/2 agonist with EC50 of 9 nM in HEK-Blue hTLR2 cells, selectively targets the TLR1/2 heterodimer. |
| PC-24869 |
KBD4466
TLR7/8 inhibitor
|
KBD4466 is a potent, highly selective inhibitor of TLR7/8 with IC50 of 0.9/2.8 nM respectively in HEK293 cellular reporter assays, does not inhibit TLR9. |
| PC-24366 |
IMDQ
TLR7/8 agonist
|
IMDQ is a highly potent, specific TLR7/8 agonist with EC50 of 8.58 nM in human TLR7-specific reporter gene assay. |
| PC-24069 |
Oxymatrine
TLR2 agonist
|
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway, also is a TLR2 agonist that directly bind to toll-like receptor 2 (TLR2). |
| PC-23645 |
TH-407b
TLR7 inhibitor
|
TH-407b is a potent and selective TLR7 inhibitor, dose-dependently inhibits R848-induced TLR7 activation with IC50 of 0.23 uM in HEK-Blue hTLR7 cells. |
| PC-22807 |
LHC165
TLR7 agonist
|
LHC165 is a potent, selective TLR7 agonist, generates effective tumor antigen-specific T-cell adaptive immune response as well as durable antitumor responses. |
| PC-22703 |
TLR2 activator R-7d
TLR2 agonist
|
TLR2 activator R-7d is a highly potent and selective human TLR2 activator with EC50 of 116 pM in human THP-1 cells, promotes TLR1/2-induced NF-κB promoter activation. |
