| Cat. No. |
Product Name |
Information |
| PC-70302 |
CL075
TLR8 agonist
|
CL075 (3M002) is a selective TLR8 agonist that induces activation of NF-κB at 0.4 uM. |
| PC-61096 |
TLR9 inhibitor 18
TLR9 inhibitor
|
TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM). |
| PC-61095 |
CPG-52364
TLR7/8/9 antagonist
|
CPG-52364 (CPG52364) is an orally available, small molecule TLR7/8/9 antagonist for the treatment of systemic lupus erythematosus and other autoimmune disorders.. |
| PC-60332 |
CU-CPT9b
TLR8 inhibitor
|
CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity. |
| PC-60331 |
CU-CPT9a
TLR8 inhibitor
|
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity. |
| PC-60002 |
CU-CPT-8m
TLR8 inhibitor
|
CU-CPT-8m is a novel potent, selective TLR8 inhibitor with Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity. |
| PC-42165 |
TL2-C29
TLR2 inhibitor
|
TL2-C29 (TLR2 inhibitor C29) is a small molecule TLR2 inhibitor that blocks hTLR2/1 and hTLR2/6 signaling with IC50 of 19.7 uM and 37.6 uM, respectively, in NF-κB reporter assay in HEK293T cells. |
| PC-28620 |
Taxifolin
TLR4 inhibitor
|
Taxifolin is a flavonoid natural compound with inhibitory activity against inflammation, malignancies, microbial infection, oxidative stress, cardiovascular disease, and liver disease, showsanti-tyrosinase activitt, exhibits significant inhibitory activity against collagenase, attenuates doxorubicin-induced heart, liver, and kidney toxicity in mice via targeting TLR4. |
| PC-28587 |
Xanthohumol
MD2 inhibitor
|
Xanthohumol is a flavonoid isolated from hops, inhibits diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, shows anti-cancer and anti-angiogenic activities, inhibits LPS-induced TLR4 pathway by antagonizing the binding sites between LPS and Myeloid differentiation 2 (MD2), also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV). |
| PC-28586 |
MD2-IN-1
MD2 inhibitor
|
MD2-IN-1 (Compound 20) is a selective small molecule inhibitor of Myeloid differentiation 2 (MD2) with anti-inflammatory properties, inhibits TLR4/MD2 complex, dose-dependent inhibits LPS-induced TNF-α and IL-6 release with IC50 of 4.27 and 2.06 uM in MPMs. |
| PC-28403 |
Monophosphoryl lipid A
TLR4 agonist
|
Monophosphoryl lipid A (MPLA) is a nontoxic derivative of lipopolysaccharide (LPS) and TRIF-biased toll-like receptor 4 (TLR4) agonist, enhances vaccine adjuvant effects and promotes Th1-type immune response and immunostimulatory properties. |
| PC-28203 |
TLR2 agonist C10
TLR2 agonist
|
TLR2 agonist C10 is a potent, selective TLR2 agonist with EC50 of 35 nM, without activating TLR3, TLR4, TLR7 or TLR8. |
