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Chemical Structure : (E)-Mirin
Catalog No.: PC-61927Not For Human Use, Lab Use Only.
Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM.
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(E)-Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM.
(E)-Mirin inhibits MRN/DSB-mediated ATM activation without affecting ATM protein kinase activity.
(E)-Mirin inhibits the MRN-dependent autophosphorylation of ATM at Ser1982 in response to DSBs.
(E)-Mirin inhibits dsDNA and resection in A549 cells with IC50 of 200-300 uM, abolishes the G2/M checkpoint and homology-directed DNA repair in mammalian cells.
| M.Wt | 220.3 | |
| Formula | C10H8N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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