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Cat. No. Product Name CAS No. Information
PC-36090

Crisdesalazine

927685-43-6 Crisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE(2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230 nM and recombinant human mPGES-1 protein with IC50 of 249 nM in vitro.
PC-49465

GS-248

1360622-01-0 Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA).
PC-49237

MPO-0144

2766397-73-1 MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM), exhibits potent neuroprotection (ED50=3.0 nM) against 6-OHDA-induced in PC12 cells without significant neurotoxicity (IC50>10 uM).
PC-38689

LY3023703

1415089-24-5 LY3023703 is a potent, highly selective microsomal prostaglandin E synthase 1 (mPGES1) inhibitor, dose-dependently inhibits PGE2 production in human whole blood ex vivo.
PC-38688

Zaloglanstat

1513852-12-4 Zaloglanstat (ISC-27864, GRC-27864) is a potent, selective, non-opioid and orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, exhibits significant analgesic efficacy in preclinical models for osteoarthritis and inflammatory arthritis.
PC-38642

SZ0232

924851-91-2 SZ0232 is a small molecule mPGES-2 (microsomal prostaglandin E synthase-2) inhibitor with IC50 of <1 uM, exhibits beneficial effects on modulating β-cell function and glucose metabolism both in vitro and in vivo.
PC-38615

CAY 10526

938069-71-7 CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression, dose-dependently inhibits PGE2 production in LPS-stimulated RAW 264.7 cells with IC50 of 1.8 uM.

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