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Chemical Structure : A-37
Catalog No.: PC-61332Not For Human Use, Lab Use Only.
A-37 is novel, potent and selective ALDH1A1 inhibitor with Ki of 300 nM and IC50 of 4.6 uM.
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A-37 is novel, potent and selective ALDH1A1 inhibitor with Ki of 300 nM and IC50 of 4.6 uM.
A-37 shows no effect on the other members of the ALDH1A subfamily (ALDH1A2 and ALDH1A3), or ALDH2 and ALDH3A1 (>100 uM).
A-37 disrupts ovarian cancer spheroid formation and cell viability, also induces moderate sensitization of IGROV1 cells to cisplatin.
| M.Wt | 431.569 | |
| Formula | C21H25N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Condello S, et al. Oncogene. 2015 Apr 30;34(18):2297-308.
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