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Chemical Structure : A293
Catalog No.: PC-72462Not For Human Use, Lab Use Only.
A293 (AVE1231) is a potent and antiarrhythmic compound and selective inhibitor of two-pore-domain potassium channel TASK-1 (KCNK3, hK2P3.1).
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A293 (AVE1231) is a potent and antiarrhythmic compound and selective inhibitor of two-pore-domain potassium channel TASK-1 (KCNK3, hK2P3.1).
A293 (AVE1231) is an inhibitor of hKv1.5 currents with predominant action on channels in their open state.
A293 (1 uM) prominently depolarized arterial smooth muscle and increased basal tone level and contractile responses to methoxamine of arteries from young rats but had almost no effect in adult rats.
Pharmacological inhibition of atrial TASK-1 currents via A293 (AVE1231) exerts antiarrhythmic effects in vivo as well as in silico, resulting in acute cardioversion of paroxysmal trial fibrillation (AF).
| M.Wt | 405.51 | |
| Formula | C20H27N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wiedmann F, et al. Cell Physiol Biochem. 2019;52(5):1223-1235.
2. Shvetsova AA, et al. Br J Pharmacol. 2020 Nov;177(22):5148-5162.
3. Wirth KJ, et al. J Cardiovasc Pharmacol. 2007 Apr;49(4):197-206.
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