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Chemical Structure : AAA237
CAS No.: 1375060-02-8
Catalog No.: PC-21767Not For Human Use, Lab Use Only.
AAA-237 (AAA237) is a small molecule Skp2 E3 ligase inhibitor, binds to Skp2 protein (KD=28.77 uM) and inhibits the degradation of Skp2 substrates, inhibits the proliferation of the NSCLC cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AAA-237 (AAA237) is a small molecule Skp2 E3 ligase inhibitor, binds to Skp2 protein (KD=28.77 uM) and inhibits the degradation of Skp2 substrates, inhibits the proliferation of the NSCLC cells.
AAA-237 has no significant effect on the mRNA expression of Skp2 but inhibits the protein expression of Skp2 in NSCLC cells in a time-dependent manner.
AAA-237 increases the expression levels of p21Cip1 and p27Kip1 in A549 and H1299 cells.
AAA-237 inhibits the proliferation of A549 and H1299 cells in a dose- and time-dependent manner, inhibits colony formation of A549 and H1299 cells.
AAA-237 arrests the cell cycle at the G0/G1 checkpoint by regulating the Skp2-Cip/Kip and PI3K/Akt-FOXO1 signaling pathways.
AAA-237 (15 or 45 mg/kg) suppresses growth of xenograft tumors by inducing apoptosis and senescence in lung cancer A549 xenograft mice model.
| M.Wt | 312.37 | |
| Formula | C17H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-N'-(4-(diethylamino)-2-hydroxybenzylidene)nicotinohydrazide |
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1. Liu J, et al. Pharmacol Res. 2022 Jul;181:106259.
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