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Chemical Structure : AB680
CAS No.: 2105904-82-1
Catalog No.: PC-35840Not For Human Use, Lab Use Only.
AB680 (Quemliclustat) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AB680 (Quemliclustat) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73).
AB680 displays > 10,000-fold selectivity against related ecto-nucleotidases (CD39, NTPDases 2/3/8) and a large panel of unrelated enzymes, receptors, and ion channels.
AB680 completely inhibits CD73 enzymatic activity on CD8+ T cell, robustly restores proliferation of human CD4+ T-cells and reverses AMPmediated inhibition of IFN-γ and IL-2 production, limits the inhibitory effect of AMP on CD4+ T cell proliferation with IC50 of 4.5 nM.
AB680 also potently restored CD25 expression on human CD8+ T cells.
| M.Wt | 580.83 | |
| Formula | C20H24ClFN4O9P2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 200 mg/mL |
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| Chemical Name/SMILES |
(((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid |
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1. Piovesan D, et al. Mol Cancer Ther. 2022 Apr 11:molcanther.0802.2021.
2. Lawson KV, et al. J Med Chem. 2020 Oct 22;63(20):11448-11468.
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