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Chemical Structure : ABBV-712
Catalog No.: PC-21236Not For Human Use, Lab Use Only.
ABBV-712 is a potent, selective inhibitor of tyrosine kinase 2 (TYK2) with EC50 of 0.01 uM, binds and stabilizes the pseudokinase (JH2) domain of TYK2.
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ABBV-712 is a potent, selective inhibitor of tyrosine kinase 2 (TYK2) with EC50 of 0.01 uM, binds and stabilizes the pseudokinase (JH2) domain of TYK2.
ABBV-712 exhibits desired TYK2 cell potency (EC50=0.19 uM) and exquisite selectivity against other JAK family members (>20 μM in cellular assays.
ABBV-712 (100, 300, and 600 mg/kg) dose-dependently inhibited IFN-γ production in IL-12/IL-18-induced IFN-γ mouse model, dose-dependently decreases ear thickness in mouse IL-23 minicircle-induced ear dermatitis model.
| M.Wt | 452.51 | |
| Formula | C24H28N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Breinlinger E, et al. J Med Chem. 2023 Oct 12. doi: 10.1021/acs.jmedchem.3c01373.
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