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Chemical Structure : ADM 12
Catalog No.: PC-62012Not For Human Use, Lab Use Only.
ADM 12 (ADM_12.
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ADM 12 (ADM_12;ADM12) is a second lipoic-containing, selective TRPA1 antagonist with IC50 of 7.3 uM for the inhibition of 30 uM menthol-induced currents in cell assay; displays little to no activity for TRPM8 and TRPV4; significantly and persistently reduces mechanical facial allodynia in rats, has potential for treatment of orofacial pain; also reverts oxaliplatin-induced neuropathy and reduces pancreatic cancer cells malignancy by inhibiting carbonic anhydrase IX (CA IX) with Ki of 650 nM, reduces CA IX-mediated acidosis.
| M.Wt | 327.48 | |
| Formula | C11H21NO4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gualdani R, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):380-5.
2. Fragai M, et al. J Med Chem. 2017 Nov 9;60(21):9003-9011.
3. Demartini C, et al. J Headache Pain. 2017 Sep 7;18(1):94.
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