Chemical Structure : AKR1C3 inhibitor SG-55
CAS No.:
AKR1C3 inhibitor SG-55
Catalog No.: PC-26001Not For Human Use, Lab Use Only.
AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.
SG-55 elevated the reduced/oxidized nicotinamide adenine dinucleotide phosphate (NADPH/NADP+) ratio, decreased the reduced/oxidized glutathione (GSH/GSSG) ratio, induced DNA double-strand breaks.
SG-55 synergized with Osimertinib to suppress proliferation, clonogenicity, and survival in 19Del/T790M/C797S mutant NSCLC cells.
SG-55 demonstrated efficacy in xenograft models and exhibited favorable pharmacokinetics in mice.
Physicochemical Properties
|
M.Wt
|
319.36
|
|
Formula
|
C19H17N3O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-{[4-(Cyclopropylcarbonyl)-1H-Pyrrol-2-yl]carbonyl}-1,2,3,4-Tetrahydroisoquinoline-7-Carbonitrile
|
References
1. Can Guo, et al. J Med Chem. 2026 Jan 29. doi: 10.1021/acs.jmedchem.5c03655.
Contact Us
sales@probechem.com
