Chemical Structure : AKR1C3 inhibitor SG-55
CAS No.:
AKR1C3 inhibitor SG-55
Catalog No.: PC-26001Not For Human Use, Lab Use Only.
AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.
SG-55 elevated the reduced/oxidized nicotinamide adenine dinucleotide phosphate (NADPH/NADP+) ratio, decreased the reduced/oxidized glutathione (GSH/GSSG) ratio, induced DNA double-strand breaks.
SG-55 synergized with Osimertinib to suppress proliferation, clonogenicity, and survival in 19Del/T790M/C797S mutant NSCLC cells.
SG-55 demonstrated efficacy in xenograft models and exhibited favorable pharmacokinetics in mice.
Physicochemical Properties
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M.Wt
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319.36
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Formula
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C19H17N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-{[4-(Cyclopropylcarbonyl)-1H-Pyrrol-2-yl]carbonyl}-1,2,3,4-Tetrahydroisoquinoline-7-Carbonitrile
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References
1. Can Guo, et al. J Med Chem. 2026 Jan 29. doi: 10.1021/acs.jmedchem.5c03655.
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