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Chemical Structure : AL3810
CAS No.: 1058137-23-7
Catalog No.: PC-35892Not For Human Use, Lab Use Only.
AL3810 (AL-3810, E-3810, Lucitanib) is a potent, orally bioavailable, multiple tyrosine kinases inhibitor, potently inhibits VEGFR1/2/3 (IC50=7-25 nM) and FGFR1/2/3 (IC50=17.5-235 nM), also inhibits CSF1R with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 100 mg | $598 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AL3810 (AL-3810, E-3810, Lucitanib) is a potent, orally bioavailable, multiple tyrosine kinases inhibitor, potently inhibits VEGFR1/2/3 (IC50=7-25 nM) and FGFR1/2/3 (IC50=17.5-235 nM), also inhibits CSF1R with IC50 of 5 nM.
AL3810 (AL-3810, E-3810, Lucitanib) shows some activity against PDGFR α and PDGFR β with 20 times lower potency, no significant activity against FGFR4 (IC50>1 uM).
AL3810 (AL-3810, E-3810, Lucitanib) causes dose-dependent inhibition of the ligand-dependent phosphorylation of VEGFR-2 and FGFR-1 in low nanomolar range in cellular assays, potently inhibits VEGF and bFGF-stimulated HUVEC proliferation with IC50 of 40-50 nM.
AL3810 (AL-3810, E-3810, Lucitanib) inhibits the growth of different human tumor xenografts in vivo.
| M.Wt | 443.503 | |
| Formula | C26H25N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(7-((1-aminocyclopropyl) methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide |
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1. Zhou Y, et al. J Cell Mol Med. 2012 Oct;16(10):2321-30.
2. Bello E, et al. Cancer Res. 2011 Feb 15;71(4):1396-405. doi: 10.1158/0008-5472.CAN-10-2700.
3. Xie Q, et al. Acta Pharmacol Sin. 2017 Nov;38(11):1533-1542.
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