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Chemical Structure : APX3330
CAS No.: 136164-66-4
Catalog No.: PC-60634Not For Human Use, Lab Use Only.
E3330 (E 3330, APX 3330, APX3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1) redox function (IC50=50 uM), but not APE1 DNA repair activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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APX3330 (E 3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1) redox function (IC50=50 uM), but not APE1 DNA repair activity.
APX3330 (E 3330) inhibits not only the growth but also the migratory abilities of pancreatic cancer cells in vitro, dramatically inhibits nuclear HIF-1α protein DNA-binding activity in PANC1 cells at >20 uM.
APX3330 (E 3330) affects cytokine-mediated hemangioblast development in vitro.
| M.Wt | 378.46 | |
| Formula | C21H30O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid |
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1. Zou GM, et al. Mol Cancer Ther. 2008 Jul;7(7):2012-21.
2. Nyland RL, et al. J Med Chem. 2010 Feb 11;53(3):1200-10.
3. Curtis CD, et al. Mol Endocrinol. 2009 Sep;23(9):1346-59.
4. Zou GM, et al. Blood. 2007 Mar 1;109(5):1917-22.
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