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Chemical Structure : ARN23746
Catalog No.: PC-72424Not For Human Use, Lab Use Only.
ARN23746 (ARN-23746) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows NKCC1 inhibition 31.8% at 10 uM, and 95.2% at 100 uM in the Cl− influx assay on NKCC1-transfected HEK293 cells.
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ARN23746 (ARN-23746) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows NKCC1 inhibition 31.8% at 10 uM, and 95.2% at 100 uM in the Cl− influx assay on NKCC1-transfected HEK293 cells.
ARN23746 did not show significant NKCC2 inhibition and KCC2 inhibition at 10 uM.
ARN23746 selectively blocks NKCC1 in a human cell line and restore the physiological [Cl−]i in murine DS neurons in culture, has excellent solubility and metabolic stability, and displays no issues with off-target activity in vitro.
ARN23746 demonstrated in vivo efficacy in rescuing cognitive impairment in a DS mouse model and social deficits and repetitive behaviors in an autism mouse model.
| M.Wt | 410.452 | |
| Formula | C17H25F3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Savardi A, et al. Chem. 2020 Aug 6;6(8):2073-2096.
2. Borgogno M, et al. J Med Chem. 2021 Jul 22;64(14):10203-10229.
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