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Chemical Structure : AS-1269574
CAS No.: 330981-72-1
Catalog No.: PC-35026Not For Human Use, Lab Use Only.
AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | $788 | In stock | |
| 1 g | Get quote |
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AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays.
AS-1269574 displays no effect towards the other GPCRs, including the β-adrenergic and GLP-1 receptors.
AS-1269574 enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions.
AS-1269574 reduces blood glucose levels, does not affect fed and fasting plasma glucose levels in mice.
| M.Wt | 308.179 | |
| Formula | C13H14BrN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol |
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1. Yoshida S, et al. Biochem Biophys Res Commun. 2010 Sep 24;400(3):437-41.
2. Chepurny OG, et al. Mol Endocrinol. 2013 Aug;27(8):1267-82.
3. Chepurny OG, et al. Mol Endocrinol. 2016 Jun;30(6):614-29.
4. McKillop AM, et al. Diabetologia. 2016 Dec;59(12):2674-2685.
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