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Chemical Structure : AUDA
Catalog No.: PC-70254Not For Human Use, Lab Use Only.
A potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 18 nM and 69 nM for mouse sEH and human sEH, respectively.
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A potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 18 nM and 69 nM for mouse sEH and human sEH, respectively; activates PPARα 3-fold at a concentration of 10 uM but exhibits no affect on PPARδ or PPARγ; decreases mean arterial blood pressure and increases urinary epoxide-to-diol ratios in angiotensin-infused rats.
| M.Wt | 392.6 | |
| Formula | C23H40N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schmelzer KR, et al. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13646-51.
2. Morisseau C, et al. Biochem Pharmacol. 2002 May 1;63(9):1599-608.
3. Fang X, et al. J Pharmacol Exp Ther. 2005 Jul;314(1):260-70.
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