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AZD-1092

Chemical Structure : AZD-1092

CAS No.: 871656-65-4

AZD-1092 (GKA-80)

Catalog No.: PC-61877Not For Human Use, Lab Use Only.

AZD-1092 (GKA-80) is a potent Glucokinase (GK) activator with EC50 of 30 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AZD-1092 (GKA-80) is a potent Glucokinase (GK) activator with EC50 of 30 nM; exhibits dose dependent reduction of glucose excursion in oral glucose tolerance tests in high fat fed female Zucker rats; shows potential for treatment of type 2 diabetes.

Physicochemical Properties

M.Wt 450.495
Formula C24H26N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[4-(1-Azetidinylcarbonyl)phenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

References

1. Coope GJ, et al. Br J Pharmacol. 2006 Oct;149(3):328-35.

2. Michael J. Waring, et al. Med. Chem. Commun., 2011, 2, 775-779

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