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AZD-2932

Chemical Structure : AZD-2932

CAS No.: 883986-34-3

AZD-2932 (AZD2932;AZD 2932)

Catalog No.: PC-45430Not For Human Use, Lab Use Only.

A potent multikinase inhibitor that inhibits PDGFRβ, VEGFR-2, Flt-3 and CSF-1R with IC50 of 4, 8, 100, and 7 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent multikinase inhibitor that inhibits PDGFRβ, VEGFR-2, Flt-3 and CSF-1R with IC50 of 4, 8, 100, and 7 nM, respectively; shows tumor growth inhibition in in vivo model; orally bioavailable.

Physicochemical Properties

M.Wt 447.4864
Formula C24H25N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL

Chemical Name/SMILES

Benzeneacetamide, 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-

References

1. Plé PA, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6.

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