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Chemical Structure : AZD-7986
CAS No.: 1802148-05-5
Catalog No.: PC-60297Not For Human Use, Lab Use Only.
AZD-7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 inhibitor with enzyme and cell pIC50 of 8.4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | $1180 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AZD-7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 inhibitor with enzyme and cell pIC50 of 8.4.
AZD-7986 (INS-1007, Brensocatib) shows excellent selectivity over other cathepsins, including cathepsins S, L, B, K, D, E, Z, H, and G.
AZD-7986 (INS-1007, Brensocatib) inhibits activation of all three NSPs (NE, Pr3, and CatG) with pIC50 of 7 in human primary bone marrow-derived CD34+ neutrophil progenitor cells.
AZD-7986 (INS-1007, Brensocatib) exhibits suitable human PK properties and is a clinical candidate for COPD.
| M.Wt | 420.469 | |
| Formula | C23H24N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide |
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1. Doyle K, et al. J Med Chem. 2016 Oct 27;59(20):9457-9472.
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