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AZD-7986

Chemical Structure : AZD-7986

CAS No.: 1802148-05-5

AZD-7986 (INS-1007, AZD7986, Brensocatib, INS1007)

Catalog No.: PC-60297Not For Human Use, Lab Use Only.

AZD-7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 inhibitor with enzyme and cell pIC50 of 8.4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD-7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 inhibitor with enzyme and cell pIC50 of 8.4.
AZD-7986 (INS-1007, Brensocatib) shows excellent selectivity over other cathepsins, including cathepsins S, L, B, K, D, E, Z, H, and G.
AZD-7986 (INS-1007, Brensocatib) inhibits activation of all three NSPs (NE, Pr3, and CatG) with pIC50 of 7 in human primary bone marrow-derived CD34+ neutrophil progenitor cells.
AZD-7986 (INS-1007, Brensocatib) exhibits suitable human PK properties and is a clinical candidate for COPD.

Physicochemical Properties

M.Wt 420.469
Formula C23H24N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

References

1. Doyle K, et al. J Med Chem. 2016 Oct 27;59(20):9457-9472.

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