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Chemical Structure : AZD-9291
CAS No.: 1421373-65-0
Catalog No.: PC-44706Not For Human Use, Lab Use Only.
Osimertinib (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 200 mg | $198 | In stock | |
| 1 g | Get quote |
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Osimertinib (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
Osimertinib (AZD-9291) shows weak activity against wt EGFR (IC50=184 nM).
Osimertinib (AZD-9291) inhibits signaling pathways and cellular growth in both EGFRm(+) and EGFRm(+)/T790M(+) mutant cell lines in vitro.
Osimertinib (AZD-9291) exhibits tumor regression in EGFR-mutant tumor xenograft and transgenic models; orally active.
| M.Wt | 499.6073 | |
| Formula | C28H33N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- |
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1. Finlay MR, et al. J Med Chem. 2014 Oct 23;57(20):8249-67.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
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