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Chemical Structure : AZD-9362
Catalog No.: PC-61142Not For Human Use, Lab Use Only.
AZD-9362 (AZD9362) is a potent, selective, orally bioavailable IGF-1R inhibitor with IC50 of 14 nM.
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AZD-9362 (AZD9362) is a potent, selective, orally bioavailable IGF-1R inhibitor with IC50 of 14 nM.
AZD-9362 weakly inhibits CDK1/2/7/8/9 with IC50 of 300-800 nM, displays good kinase selectivity in a panel of 60 kinases.
AZD-9362 inhibits the auto-phosphorylation of IGF-1R after IGF1 stimulation in mice fibroblasts with IC50 of 48 nM, inhibits IGF-driven growth of tumour allografts.
| M.Wt | 494.984 | |
| Formula | C24H27ClN8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Degorce SL, et al. J Med Chem. 2016 May 26;59(10):4859-66.
2. Fox EM, et al. Breast Cancer Res. 2013;15(4):R55.
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