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Chemical Structure : Alpha-NETA free base
Catalog No.: PC-61078Not For Human Use, Lab Use Only.
Alpha-NETA is a selective choline acetyltransferase (ChA) inhibitor with IC50 of 9 uM, also is a TAAR5 agonist that affects sensory gating in rats.
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Alpha-NETA free base is a selective choline acetyltransferase (ChA) inhibitor with IC50 of 9 uM, also is a TAAR5 agonist that affects sensory gating in rats.
Alpha-NETA antagonizes the effects of acetylcholine (ED50=70-80 uM) histamine and KCl-induced contractions in the guinea pig longitudinal ileal muscle, activates acetylcholinesterase (EC50=360 uM) and inhibits cholinesterase (EC50=1100 uM) at high concentrations.
Alpha-NETA also is a CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration, suppresses CNS autoimmune inflammatory disease in vivo.
| M.Wt | 369.246 | |
| Formula | C16H20INO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sastry BV, et al. J Pharmacol Exp Ther. 1988 Apr;245(1):72-80.
2. Graham KL, et al. PLoS One. 2014 Dec 1;9(12):e112925.
3. Tümmler C, et al. Oncotarget. 2017 Jul 27;8(56):95135-95151.
4. Aleksandrov AA, et al. Neurosci Lett. 2017 Dec 27;666:144-147.
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