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Chemical Structure : Azaindole-1
CAS No.: 867017-68-3
Catalog No.: PC-42519Not For Human Use, Lab Use Only.
A potent, highly selective, ATP-competitive ROCK inhibitor with IC50 of 0.5/1.1 nM for ROCK1/ROCK2 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $411.2 | In stock | |
| 50 mg | $1121.6 | In stock | |
| 100 mg | $1645.6 | In stock |
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A potent, highly selective, ATP-competitive ROCK inhibitor with IC50 of 0.5/1.1 nM for ROCK1/ROCK2 respectively; weak activity on Trk and FLT3; induced a dose-dependent decrease in blood pressure in vivo and orally active.
| M.Wt | 402.7852 | |
| Formula | C18H13ClF2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, 6-chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]- |
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1. Kast R, et al. Br J Pharmacol. 2007 Dec;152(7):1070-80.
2. Pankey EA, et al. Can J Physiol Pharmacol. 2012 Jul;90(7):825-35.
3. Lasker GF, et al. Urology. 2013 Feb;81(2):465.e7-14.
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