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Chemical Structure : BAY-885
CAS No.: 2307249-33-6
Catalog No.: PC-35332Not For Human Use, Lab Use Only.
BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 25 mg | $558 | In stock | |
| 100 mg | $1380 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel).
BAY-885 strongly inhibits EGF-stimulated MEF2 transcriptional activity in MEF2 reporter assay with IC50 of 115 nM.
Despite its high potency, BAY-885 failed to inhibit the proliferation of cells with ERK5 genomic amplification (SN12C, SNU-449, MFM-223) or with constitutively active ERK5 signaling (BT-474, SK-BR-3).
| M.Wt | 515.541 | |
| Formula | C25H28F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone |
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1. Clara Lemos, et al. Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885. AACR. 2018.
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