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Chemical Structure : BCL6 inhibitor 79-6
CAS No.: 301356-95-6
Catalog No.: PC-60926Not For Human Use, Lab Use Only.
BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM.
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|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
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BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM.
BCL6 inhibitor 79-6 binds to a pocket in the lateral groove of the BCL6 BTB domain, specifically inhibits BCL6 but not other BTB-ZF proteins.
BCL6 inhibitor 79-6 disrupts BCL6/corepressor complexes and reactivates BCL6 target genes in vitro and in vivo, selectively kills BCL6-dependent DLBCL cells.
BCL6 inhibitor 79-6 suppresses human DLBCL xenografts in mice with favorable pharmacokinetics.
| M.Wt | 457.269 | |
| Formula | C15H9BrN2O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-2-(5-(5-bromo-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)succinic acid |
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1. Cerchietti LC, et al. Cancer Cell. 2010 Apr 13;17(4):400-11.
2. Cardenas MG, et al. J Clin Invest. 2016 Sep 1;126(9):3351-62.
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