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Chemical Structure : BFH-772
CAS No.: 890128-81-1
Catalog No.: PC-42146Not For Human Use, Lab Use Only.
A potent, selective and orally active VEGFR2 tyrosine kinase inhibitor with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $96 | In stock | |
| 10 mg | $160 | In stock | |
| 25 mg | $320 | In stock | |
| 50 mg | $576 | In stock |
Bulk size, bulk discount!
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A potent, selective and orally active VEGFR2 tyrosine kinase inhibitor with IC50 of 3 nM; shows 40-fold less potent activity B-RAF, RET and TIE-2, and >500-fold for FLK-1, FLT-1 and FLT-4; inhibits ligand-induced autophosphorylation of RET, PDGFR and KIT with IC50 of 30-160 nM, potently inhibits VEGF-driven angiogenesis in a chamber model and rodent tumor models at daily doses of less than 3 mg/kg.
Psoriasis
Phase 2 Discontinued
| M.Wt | 439.3867 | |
| Formula | C23H16F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 7.75 mg/mL |
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| Chemical Name/SMILES |
1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]- |
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1. Bold G, et al. J Med Chem. 2016 Jan 14;59(1):132-46.
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