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Chemical Structure : BI 1810284
Catalog No.: PC-20464Not For Human Use, Lab Use Only.
BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.
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BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.
BI 1810284 (80 mg/kg, oral) induces lung cancer tumour growth inhibition in A549 tumour bearing mice.
| M.Wt | 1063.19 | |
| Formula | C57H69BrFN7O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Christiane Kofink, et al. Nat Commun. 2022 Oct 10;13(1):5969.
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