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Chemical Structure : BMS-751324
Catalog No.: PC-63564Not For Human Use, Lab Use Only.
BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM.
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BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM.
BMS-751324 is effectively bioconverted into parent drug BMS-582949 in vivo by alkaline phosphatase and esterase in a stepwise manner.
BMS-751324 demonstrates similar efficacy in rat LPS-induced TNFα pharmacodynamic model and rat adjuvant arthritis model compared with BMS-582949.
BMS-751324 is indeed effective in addressing the pH-dependent absorption issue associated with BMS-582949.
| M.Wt | 694.638 | |
| Formula | C32H35N6O10P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu C, et al. J Med Chem. 2015 Oct 8;58(19):7775-84.
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