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BRD1240

Chemical Structure : BRD1240

CAS No.: 1304759-66-7

BRD1240 (BRD 1240)

Catalog No.: PC-62141Not For Human Use, Lab Use Only.

BRD1240 is a small-molecule probe that can suppress V-ATPase function, inhibits lysosomal acidification and blocks the maturation of autophagosomes to autolysosomes.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BRD1240 is a small-molecule probe that can suppress V-ATPase function, inhibits lysosomal acidification and blocks the maturation of autophagosomes to autolysosomes; increases autophagosome number by inhibiting autophagosomal turnover, blocks the later stages of autophagy.

Physicochemical Properties

M.Wt 592.667
Formula C30H32N4O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(benzo[d][1,3]dioxol-5-yl)-1-(((4S,5S)-2-((S)-1-hydroxypropan-2-yl)-4-methyl-1,1-dioxido-8-(pyridin-4-ylethynyl)-2,3,4,5-tetrahydrobenzo[b][1,4,5]oxathiazocin-5-yl)methyl)-1-methylurea

References

1. Aldrich LN, et al. J Am Chem Soc. 2015 Apr 29;137(16):5563-8.

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