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Chemical Structure : BSJ-05-037
Catalog No.: PC-20466Not For Human Use, Lab Use Only.
BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78.
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BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78.
BSJ-05-037 induces potent degradation of ITK dependent on CRBN, neddylation, and the proteasome.
BSJ-05-037 induces GATA-3 loss and decreases chemotherapy resistance in vitro.
BSJ-05-037 disrupts TCR signaling, downregulates the Th2-associated transcription factor GATA-3, and can overcome chemotherapy resistance in TCL models in vivo.
| M.Wt | 1022.21 | |
| Formula | C51H59N9O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jiang B, et al. Cell Chem Biol. 2023 Mar 27:S2451-9456(23)00086-7.
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