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BTK inhibitor 4b

Chemical Structure : BTK inhibitor 4b

CAS No.: 1646608-10-7

BTK inhibitor 4b

Catalog No.: PC-35698Not For Human Use, Lab Use Only.

BTK inhibitor 4b is a potent, highly selective inhibitors of BTK with IC50 of 4.2 and 0.9 nM against activated and unactivated BTK, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BTK inhibitor 4b is a potent, highly selective inhibitors of BTK with IC50 of 4.2 and 0.9 nM against activated and unactivated BTK, respectively; demonstrates significant efficacy in models in vivo and good ADME and safety profiles.

Physicochemical Properties

M.Wt 498.522
Formula C26H23FN8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3-{4-Amino-6-[(1-methyl-1H-pyrazol-4-yl)amino]-1,3,5-triazin-2-yl}-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one

References

1. Kawahata W, et al. J Med Chem. 2018 Oct 11;61(19):8917-8933.

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