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Chemical Structure : BTT-369
Catalog No.: PC-35727Not For Human Use, Lab Use Only.
BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays.
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BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays.
BTT-369 decreases trafficking of CaV2.2 channels to the plasma membrane and modulates the functions of the channel, suppresses pain responses in rodent neuropathic pain models.
BTT-369 (BTT369) is a cell-permeable derivative of BTT-266.
| M.Wt | 580.652 | |
| Formula | C34H28N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen X, et al. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10566-E10575.
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