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BX-667

Chemical Structure : BX-667

CAS No.: 937395-08-9

BX-667 (BX667;BX 667)

Catalog No.: PC-61586Not For Human Use, Lab Use Only.

BX-667 is a potent P2Y12 receptor antagonist that blocks ADP-induced platelet aggregation in human, dog and rat blood (IC50=97, 317 and 3000 nM respectively).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BX-667 is a potent P2Y12 receptor antagonist that blocks ADP-induced platelet aggregation in human, dog and rat blood (IC50=97, 317 and 3000 nM respectively); a potential antiplatelet therapeutic agent.

Physicochemical Properties

M.Wt 586.64
Formula C29H38N4O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-(4-((1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy)-7-methylquinoline-2-carboxamido)-5-(4-(ethoxycarbonyl)piperazin-1-yl)-5-oxopentanoic acid

References

1. Wang YX, et al. Thromb Haemost. 2007 May;97(5):847-55.

2. Bryant J, et al. Thromb Res. 2008;122(4):523-32.

3. Post JM, et al. Thromb Res. 2008;122(4):533-40.

4. Siller-Matula JM, et al. Br J Pharmacol. 2010 Feb 1;159(3):502-17.

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