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Chemical Structure : Bafilomycin A1
CAS No.: 88899-55-2
Catalog No.: PC-22177Not For Human Use, Lab Use Only.
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 of 4-400 nM, also is an autophagy inhibitor, blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes.
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Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 of 4-400 nM, also is an autophagy inhibitor, blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes.
| M.Wt | 622.84 | |
| Formula | C35H58O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3Z,5Z,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-((2R,4R,5S,6R)-2,4-Dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one |
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1. Bowman EJ, et al. Proc Natl Acad Sci U S A. 1988;85(21):7972-7976.
2. Mauvezin C, et al. Autophagy. 2015;11(8):1437-1438.
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