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Chemical Structure : Bay 65-1942
CAS No.: 600734-02-9
Catalog No.: PC-45916Not For Human Use, Lab Use Only.
Bay 65-1942 (BAY651942) is a potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Bay 65-1942 (BAY651942) is a potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM.
Bay 65-1942 (BAY651942) dispalys >50-fold selectivity over IKK-α, does not inhibit (IC50>10 uM) IKK3, MKK4, MKK7, ERK-1, Syk, Lck, Fyn, PI3Kγ, PKA, and PKC.
Bay 65-1942 (BAY651942) inhibits stress-induced NF-kappaB transactivation, chemokine-, cytokine-, and adhesion molecule expression, and T- and B-cell proliferation.
Bay 65-1942 (BAY651942) inhibits cockroach allergen-induced airway inflammation and hyperreactivity and efficiently abrogates leukocyte trafficking induced by carrageenan in mice.
| M.Wt | 395.4516 | |
| Formula | C22H25N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Pyrido[2,3-d][1,3]oxazin-2-one, 7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-(3S)-3-piperidinyl- |
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1. Noha SM, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):577-83.
2. Ziegelbauer K, et al. Br J Pharmacol. 2005 May;145(2):178-92.
3. Moss NC, et al. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53.
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