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Chemical Structure : Bictegravir
CAS No.: 1611493-60-7
Catalog No.: PC-61944Not For Human Use, Lab Use Only.
Bictegravir (GS 9883) is a potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Bictegravir (GS 9883) is a potent HIV-1 integrase (IN) that specifically targets IN strand transfer activity with IC50 of 7.5 nM.
Bictegravir (GS 9883) exhibits potent and selective in vitro antiretroviral activity in both T-cell lines and primary human T lymphocytes with EC50 of 1.5-2.4 nM, with minimal cytotoxicity;.
Bictegravir (GS 9883) exhibits synergistic in vitro antiviral effects in pairwise combinations with tenofovir alafenamide, emtricitabine, or darunavir and maintains potent antiviral activity against HIV-1 variants.
| M.Wt | 449.39 | |
| Formula | C21H18F3N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
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1. Tsiang M, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097.
2. Gallant JE, et al. J Acquir Immune Defic Syndr. 2017 May 1;75(1):61-66.
3. Hassounah SA, et al. Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01695-17.
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