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Chemical Structure : C-type natriuretic peptide
Catalog No.: PC-72558Not For Human Use, Lab Use Only.
C-type natriuretic peptide (CNP, pGC-B activator) is the native particulate guanylyl cyclase B receptor (pGC-B) activator.
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C-type natriuretic peptide (CNP, pGC-B activator) is the native particulate guanylyl cyclase B receptor (pGC-B) activator.
CNP induces anti-remodeling actions in the heart and kidney through the generation of the second messenger cGMP.
CNP selectively activates pGC-B and generates cGMP in vitro.
CNP is abundantly expressed in the endothelium and kidneys as well as the heart, but to lesser extent than trial natriuretic peptide (ANP) and b-type natriuretic peptide (BNP).
CNP is produced as a prohormone that is cleaved intracellularly by the enzyme, furin, to yield a 53-AA intermediate form (C53).
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1. Kuhn M. Physiol Rev. 2016 Apr; 96(2):751-804.
2. Stingo AJ, et al. Am J Physiol. 1992 Oct; 263(4 Pt 2):H1318-21.
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