| Cat. No. |
Product Name |
Information |
| PC-49581 |
BI 685509
sGC activator
|
BI 685509 (Avenciguat) is a potent, selective and orally bioavailable soluble guanylate cyclase (sGC) activator, increases cGMP in human and rat platelet-rich plasma treated with ODQ with EC50 of 467 nM and 304 nM, respectively. |
| PC-72945 |
BAY-747
sGC stimulator
|
BAY-747 (BAY 1165747, BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator with MEC value of 0.06 uM for stimulation of cGMP formation. |
| PC-72557 |
MCUF-651
Guanylyl cyclase A receptor PAM
|
MCUF-651 (MCUF651) is a small molecule guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM), potentiate ANP-mediated cGMP with EC50 of 0.45 uM (Emax=82%) in HEK293 GC-A cells. |
| PC-36097 |
Runcaciguat
|
Runcaciguat is a potent soluble guanylyl cyclase (sGC) stimulator/activator, binds and activates oxidized and heme-free sGC and thereby restores NO-sGC-cGMP signaling under oxidative stress. |
| PC-61605 |
Vericiguat
|
Vericiguat (BAY 1021189) is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator (MEC=0.3 uM), stimulating sGC NO-independently and in synergy with NO. |
| PC-60523 |
Olinciguat
sGC stimulator
|
Olinciguat (IW-1701, IW1701) is a novel potent, selective soluble guanylate cyclase (sGC) stimulator, enhances the synthesis of cGMP in response to NO binding. |
| PC-60050 |
Praliciguat
sGC stimulator
|
Praliciguat (IW-1973, IW1973) is a potent, orally available soluble guanylate cyclase (sGC) stimulator that concentration-dependently increases the production of cGMP with EC50 of 267 nM. |
| PC-44126 |
Lificiguat
|
Lificiguat (YC-1) is an NO-independent, superoxide-sensitive stimulator of sGC (soluble guanylyl cyclase) with EC50 of 18.6 uM. |
| PC-45991 |
Nelociguat
sGC stimulator
|
Nelociguat (BAY60-4552) is a direct soluble guanylate cyclase (sGC) stimulator that acts independently of nitric oxide (NO). |
| PC-21208 |
Cinaciguat
sGC activator
|
Cinaciguat (BAY 58-2667) is a potent, small molecule activator of guanylate cyclase (sGC) with binding Kd of 3.2 nM, potently activates sGC in an NO-independent manner. |
| PC-20917 |
Riociguat
sGC stimulator
|
Riociguat (BAY 63-2521) is a potent, orally active stimulator of soluble guanylate cyclase (sGC) with MEC of 0.03 uM for achieve threefold stimulation of cGMP formation in recombinant sGC-overexpressing cell line. |
| PC-38368 |
Mosliciguat
sGC activator
|
Mosliciguat is a small molecule soluble guanylate cyclase (sGC) activator. |
