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Chemical Structure : C101248
CAS No.: 361368-24-3
Catalog No.: PC-49461Not For Human Use, Lab Use Only.
C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1.
C101248 is selective for THIK-1 and is inactive against K2P family members TREK-1 and TWIK-2, and Kv2.1.
C101248 potently blocked both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of microglia from mouse hippocampal slices.
C101248 had no effect on other constitutively active resting conductance in slices from THIK-1-depleted mice.
C101248 attenuated the NLRP3-dependent release of IL-1β from microglia.
| M.Wt | 292.302 | |
| Formula | C15H12N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(1-(pyridin-4-ylmethyl)-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine |
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1. Bernardino Ossola, et al. Neuropharmacology. 2022 Nov 11;109330
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