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Chemical Structure : CAN-508
CAS No.: 140651-18-9
Catalog No.: PC-62864Not For Human Use, Lab Use Only.
CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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CAN-508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM); reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays; decreases phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II, inhibits mRNA synthesis, and induces the tumor suppressor protein p53.
| M.Wt | 218.22 | |
| Formula | C9H10N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[(3,5-diamino-1H-pyrazol-4-yl)azo]-phenol |
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1. Krystof V, et al. J Med Chem. 2006 Nov 2;49(22):6500-9.
2. Kryštof V, et al. Eur J Med Chem. 2011 Sep;46(9):4289-94.
3. Tong Z, et al. Oncotarget. 2017 Apr 25;8(17):28696-28710.
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