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CB-988

Chemical Structure : CB-988

CAS No.:

CB-988 (CB988;CB 988)

Catalog No.: PC-61951Not For Human Use, Lab Use Only.

CB-988 is a potent, highly selective, non-covalent Btk inhibitor targering ibrutinib-resistant Btk C481S mutant (IC50=0.6 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CB-988 is a potent, highly selective, non-covalent Btk inhibitor targering ibrutinib-resistant Btk C481S mutant (IC50=0.6 nM); inhibits activated Btk and unactivated Btk with IC50 of 0.78 and 0.09 nM, strongly reduces p-Tyr223 and the proliferation of OCI-Ly10 cells.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

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